Police are appealing for witnesses and information about a burglary at Weyhill Texaco Garage near Andover between 2am and 3am on Tuesday, July 1.
During the raid, unknown offenders made a large hole in an external wall at the rear of the building and then forced their way through internal walls to gain access to the office of the garage.
The safe was removed from the office and opened outside of the garage.
Cash, which was in the safe, was stolen and about £10,000 worth of cigarettes and tobacco was also taken.
Detective Constable Alix Davis said: “It is believed the offenders would have needed a large vehicle, maybe a 4×4, to get to the rear of the premises and also to have pulled the safe from the building.
“If you saw any large vehicles in suspicious circumstances, or have any information which could assist this investigation, please contact me as soon as possible.”
Anyone with information is asked to contact DC Davis at Andover Police Station on 101 or call the Crimestoppers charity anonymously on 0800 555 111.